ABSTRACT
<p><b>OBJECTIVE</b>To observe the clinical efficacy of Yinzhihuang Oral Liquid (YOL) to prevent the premature infantile jaundice.</p><p><b>METHODS</b>After excluded hemolytic, suffocation, infection, and the very low birth weight, 242 cases of premature infants were randomly assigned to two groups, the treatment group and the control group. Both groups were taken conventional procedures, such as warmth, feeding, and blood glucose monitoring, and the treated group was administered YOL 5 mL each time, twice daily additionally, and the control group without any treatment. The percutaneous bilirubin and blood cells were observed every day.</p><p><b>RESULTS</b>Compared the two groups, the jaundice indices were more significantly different at 24-48 h, 48-72 h, and more than 72 h (P<0.05), but not statistically different at 0-24 h (P>0.05). Hemoglobin, reticulocyte, platelets, and leucocyte were not significantly different between the two groups (P>0.05).</p><p><b>CONCLUSION</b>YOL as an early intervention has positive significance to decrease the incidence of pathological jaundice in the premature infants, and no significant impact on the blood cells.</p>
Subject(s)
Female , Humans , Infant, Newborn , Male , Administration, Oral , Bilirubin , Metabolism , Blood Cells , Metabolism , Dosage Forms , Drug Administration Schedule , Drugs, Chinese Herbal , Infant, Premature , Infant, Premature, Diseases , Jaundice, Neonatal , Skin , Metabolism , Treatment OutcomeABSTRACT
<p><b>OBJECTIVE</b>Mutations in NPHS2 mapped to 1q25-q31 and encoding podocin, which is exclusively expressed in glomerular podocytes, are responsible for autosomal recessive familial steroid-resistant nephrotic syndrome (SRNS) with minor glomerular abnormalities or focal segmental glomerulosclerosis. Different groups from European and North American countries have screened NPHS2 mutations in familial SRNS with recessive inheritance, documenting a mutation detection rate of 45% - 55% in families. This study aimed to examine mutations in the NPHS2 gene in Southern Chinese Han ethnic group patients with familial SRNS.</p><p><b>METHODS</b>Genomic DNA from 3 probands from Southern Chinese Han families with autosomal recessive SRNS, and their siblings and parents was isolated and analyzed for all eight exons, exon-intron boundaries and promoter of NPHS2 using the polymerase chain reaction and direct sequencing.</p><p><b>RESULTS</b>No mutation of NPHS2 in all eight exons and exon-intron boundaries was identified in the 3 probands. However, a polymorphism of 954T > C in exon 8 was detected in all the 3 probands and some controls, and 5 variants of NPHS2 promoter, -1709G > A, -1000A > T, -670C > T, -116C > T and -51G > T, were identified in some patients and controls, indicating that these variants are polymorphisms. One heterozygous variant of NPHS2 promoter, -1715A > G, was also identified in one proband and her mother whose urinalyses were normal, whereas it was not found in any of the 50 controls. There was no significant difference in the allelic frequencies of -1709G > A, -1000A > T, -670C > T, -116C > T and -51G > T polymorphisms between the patients and controls.</p><p><b>CONCLUSION</b>NPHS2 mutations are not a major cause of familial steroid-resistant nephrotic syndrome in Southern Chinese Han ethnic group included in the study.</p>
Subject(s)
Adolescent , Child , Child, Preschool , Female , Humans , Infant , Male , Asian People , Genetics , Gene Frequency , Intracellular Signaling Peptides and Proteins , Genetics , Membrane Proteins , Genetics , Mutation , Nephrotic Syndrome , Ethnology , Genetics , PedigreeABSTRACT
<p><b>OBJECTIVE</b>To study the effect of Simotang oral liquid and glycerin enema on the patients' bowel sound (BS) restoration and anal exhaust after abdominal gynecological operation.</p><p><b>METHOD</b>Ninety patients with benign tumor who had undergone gynecological operation were randomly divided into the Simotang group, treated after operation with Simotang oral liquid; the enema group, treated with glycerin enema, and the control group, non-treated. The restoration time of BS and anal exhaust were observed.</p><p><b>RESULTS</b>Compared with the control group, the restoration time of BS and anus exhaust were both significantly shorter in the Simotang group and the enema group, showing statistical significance (P < 0.05); but the difference between the two treated groups was insignificant (P > 0.05).</p><p><b>CONCLUSION</b>Simotang oral liquid and glycerine enema both could benefit the restoration of anal exhaust and BS after abdominal operation.</p>